Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger’s syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race. Despite this initial resentment, as an adult Zakir sponsors Rizwan to come and live with him in San Francisco after the death of their mother. It is at this time that Zakir’s wife, Haseena diagnoses Rizwan as having Asperger’s syndrome. Rizwan also begins to work for Zakir and in the process he meets a Hindu woman, Mandira (Kajol) and her young son, Sameer, from a previous marriage. Despite Zakir’s hostility to the match, they marry and settle down in the fictional town of Banville, where both Mandira and Sameer take Rizwan’s last name as their own. They also live next door to the Garrick family, consisting of Mark, who is a reporter, his wife Sarah and son Reese.